A COVID-19 cell looks up a wall of genomic code.

In an unprecedented international effort, researchers and clinicians tackle the genomics of COVID-19 risk.

by Robert C. Green

Why does COVID-19 affect some people differently than others? Are some people more likely to contract it than others, even if they’ve had the same exposure? After contracting COVID, why do some apparently healthy people have an unexpectedly severe response?

For anyone involved in genomic medicine, the next question is obvious: How much of this is genetic?

Answering that question is more difficult than it may seem. The SARS-CoV-2 coronavirus has more than 12,700 identified mutations, at least five strains, and somewhere…

by Nic Encina

The Golden Gate Bridge under construction, with the superscript “Follow-Through”

Our recent launch of Precision Population Health officially introduced Ariadne Labs into the world of precision medicine. Since being founded in 2012, Ariadne Labs has specialized in developing scalable systems-level solutions for life’s most critical moments and the stages in between — such as surgery, maternal health, serious illness and palliative care, and primary health care. Although our work may not have dealt directly with precision medicine, we were far from removed from it. Ariadne Labs was founded and built in the image of The Broad Institute. Many of our faculty and staff participated in the Human…

by Sachi Badola

A woodcut-style illustration of a school, framed by DNA helixes
The complexity of practicing precision medicine begins in a high school classroom.

What does genetics mean to me?

Taking a step back into my seventh-grade life science class, we discussed the concepts of heredity. Genes, alleles, the structure of DNA. The one and only Gregor Mendel and his pea plants. The foundational knowledge of genetics. Freshman year, we dove deeper into the concept of protein synthesis. How does the central dogma allow genetic information to pass from DNA to RNA to protein? Sophomore year, we continued our investigation of genetics in AP Biology. Genetic diseases, chromosomal abnormalities, Punnett square analysis. …

by Cathelijne van der Wouden

The author stands in front of a poster on “Consumer Discussion of DTC Genomic Testing Results with Primary Care Providers”

Pharmacists-in-training don’t usually get involved in genomics research. As graduate students in a PharmD program at Utrecht University in The Netherlands, my peers and I were on the way to becoming pharmacists. Our program only covered basic genomics, since — at least traditionally — genomics is not considered essential knowledge for pharmacists. But I was intrigued to learn why certain patients respond differently to the same drug regimen, and the most fundamental way to describe human variation is through genomics.

Driven by this curiosity, I reached out to the Genomes2People Research Program (G2P) in the…

Race is a social construct, but representation matters in genetic studies — and on that front, we have a long way to go. By Tala Berro

An artist’s representation of the earth from space, with images of chromosomes superimposed on the planet

By Tala Berro

I am a Palestinian American. On the census, under the racial category, I am instructed to mark the box labeled “white.” Why am I classified as white? On doing a deeper dive about this, I found out that the older Arab generations wanted this classification in order to better assimilate. This did help many lighter-skinned Arabs to assimilate, yet there is still a history of people from SWANA (Southwest Asia, North…

By Elizabeth Fieg

Illustration of a genetic counselor considering a medical chart
Genetic counselors are the key to increasing patient access to valuable genetic healthcare services; passing the H.R. 3235 bill is the key to increasing patient access to genetic counselors.

Genetic testing is more accessible than ever, thanks to an increase in public awareness and the continuously decreasing costs of genetic sequencing. Genetic information is being used to diagnose rare disorders, develop targeted and novel therapies, facilitate reproductive planning, guide treatment decisions, and inform people of their risk to develop certain medical problems. The decision of whether or not to pursue genetic testing can be complex and difficult, and many people benefit from meeting with a genetic counselor to understand the benefits and limitations of their options.

Genetic counselors are important health care providers who are uniquely…

By Dr. Robert C. Green

Let’s say it was possible to buy your health by the day. How much would you be willing to pay for each year of perfect health? What if you could buy years of health for your loved ones, too? At what price point would you draw the line?

This sort of difficult calculus, on a much larger and chronologically longer scale, underpins many decisions we make in medicine — not just decisions that we make as patients, but also the decisions that are made for us by employers, health insurance funders and policymakers. We don’t…

By Dr. Robert C. Green

If you’re an apparently healthy person who wants to learn about your genetic disease risks, you can send a saliva sample and a hundred bucks or so to an array-based direct-to-consumer genetic testing company and get some trait information and selected health risks, plus details about your genetic ancestry. But as the direct-to-consumer (DTC) companies themselves will tell you, this is only a fraction of the medical value that may be hidden in your genome. …

Continuous new discoveries about the genome make updates important.

Learn more about The MedSeq Project.

by Robert C. Green

The doctor hands you a report. Your genome has just been sequenced and analyzed, and this report tells you about several potential medical issues you should be paying attention to, based on what variants turned up in your genome. Now you can move forward with this knowledge, taking actions if necessary, and put the whole genome sequencing thing behind you. Right?

Not exactly. If those same genome sequencing results are re-analyzed in two years, or even in six months, it is…

When a newborn’s genome is sequenced, should some results be withheld?

Learn more about the BabySeq Project.

By Robert C. Green

If genome sequencing can warn us of future disease risks, allowing the opportunity for intervention before symptoms appear, it stands to reason that the earlier you obtain it, the more you will benefit. And if earlier is better, wouldn’t newborn genome sequencing make sense?

It very well might. A simple “heel stick” newborn genetic screening test, covering over 30 conditions, is already required by law in the U.S. and many other countries. Genome sequencing goes much further, searching for…


The G2P Research Program (www.genomes2people.org) is focused on the judicious integration of genomic research into personalized medicine & clinical practice.

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